By-Laws of the Potrero and Bay View Railroad Company, of the City and County of San Francisco:Incorporate April 4th, 1866 (Classic Reprint) Potrero and Bay View Railroad Company
This book proposes a new way to think about evolution. The author carefully brings together evidence from diverse fields of science. In the process, he bridges the gaps between many different--and usually seen as conflicting--ideas to present one integrative theory named ONCE, which stands for Organic Nonoptimal Constrained Evolution. The author argues that evolution is mainly driven by the behavioral choices and persistence of organisms themselves, in a process in which Darwinian natural selection is mainly a secondary--but still crucial--evolutionary player. Within ONCE, evolution is therefore generally made of mistakes and mismatches and trial-and-error situations, and is not a process where organisms engage in an incessant, suffocating struggle in which they cant thrive if they are not optimally adapted to their habitats and the external environment. Therefore, this unifying view incorporates a more comprehensive view of the diversity and complexity of life by stressing that organisms are not merely passive evolutionary players under the rule of external factors. This insightful and well-reasoned argument is based on numerous fascinating case studies from a wide range of organisms, including bacteria, plants, insects and diverse examples from the evolution of our own species. The book has an appeal to researchers, students, teachers, and those with an interest in the history and philosophy of science, as well as to the broader public, as it brings life back into biology by emphasizing that organisms, including humans, are the key active players in evolution and thus in the future of life on this wonderful planet. Rui Diogo is an Associate Professor at Howard University College of Medicine and a member of the Resource Faculty at the Center for the Advanced Study of Hominid Paleobiology at George Washington University. One of the youngest researchers to be nominated as Fellow of the American Association of Anatomists, he won several prestigious awards, being the only researcher to be selected for the first/second place for best article of the year in the top anatomical journal two times in just three years (2013/2015). Author or co-author of more than 100 papers in top journals, such as Nature, and of numerous book chapters, he is the co-editor of three books and the sole or first author of eleven books covering subjects as diverse as fish evolution, chordate development, and human medicine and pathology, including a book adopted at medical schools worldwide, Learning and understanding human anatomy and pathology: an evolutionary and developmental guide for medical students.
This volume based on an international and interdisciplinary conference in 2014 provides an assessment of the developments after the upheavals in the Southern Mediterranean with regard to the challenges for the European Foreign and Security Policy. Besides a review of the European Neighbourhood Policy and the experiences of the European External Action Service in the countries of the Southern periphery, the analysis considers economic and social dynamics across the Mediterranean as well as challenges from societal actors, especially Islamist groups with regard to regional developments and European politics. Furthermore, the volume incorporates the view of the eminent regional actors Turkey and Israel and explains their responses towards the regional developments. With contributions by: Steffen Angenendt, Maximilian Benner, Dustin Dehez, Çagri Erhan, Burak Küntay, Baran Kusoglu, Amichai Magen, Piril Ocak, Sharon Pardo, Silvia Popp, Alessandro Quarenghi, Stephan Roll, Julia Simon und Jan ?naidauf.
Not enough religion in science, not enough science in religion: where and when will a world view emerge which incorporates and transcends these two determining aspects of our civilization? Hubert Benoit was someone who incorporated these conflicting perspectives creatively into his work as a psychotherapist. This book was completed towards the end of his life and contains a distillation of his thoughts and experience.
The fourth edition of Jane Austen´s Letters incorporates the findings of new scholarship to enrich our understanding of Austen and give us the fullest view yet of her life and family. The biographical and topographical indexes have been updated, a new subject index has been created, and the contents of the notes added to the general index.
Todays views of leadership and management have significantly expanded to incorporate a variety of elements such as rewards, visions, and worker participation. However, most perspectives still view leadership as something that is assigned to a designated p
Greek historiography engaged with past and present time; but how exactly did this engagement incorporate claims to knowing the future? Considering prognosis as rooted in historiographical temporalities this volume reads historians from Herodotus to Appian with a view to exploring configurations of future time in the context of ancient and modern reflections on the historical as well as the ethical and political role of historiographical practice.
?This notable collection provides an interdisciplinary platform for prominent thinkers who have all made significant recent contributions to exploring the nexus of philosophy and narrative. It includes the latest assessments of several key positions in the current philosophical debate. These perspectives underpin a range of thematic strands exploring the influence of narrative on notions of selfhood, identity, temporal experience, and the emotions, among others. Drawing from the humanities, literature, history and religious studies, as well as philosophy, the volume opens with papers on narrative intelligence and the relationship between narrative and agency. It features special sections of in-depth commentary on a range of topics. How, for example, do narrative and philosophical biography interact? Do celebrated biographical and autobiographical accounts of the lives of philosophers contribute to our understanding of their work? This new volume has a substantive remit that incorporates the intercultural religious view of philosophys links to narrative together with its many secular aspects. A valuable new resource for more advanced scholars in all its constituent disciplines, it represents a significant addition to the literature of this richly productive area of research.
Biopharmaceutical medicinal products (biologics) represent a huge financial market. Thus upon patent protection expiry of the innovator (reference) biologic there is interest from industry to gain a portion of this market by launching a similar biologic at a reduced development cost, thus boosting potential gains. The EMA responded to this desire and lead the guidance process with industry on the topic of biosimilars. Based on the experience gained with biosimilars in the past, the EMA started to introduce a second generation series of guidance documents, which take into account the past, current and possibly future challenges of biosimilars. Those proposals were evaluated by EMA and partially incorporated into new guidance documents. This work highlights the challenges and risks associated with biosimilar submissions for large and complex bio-molecules such antibodies. Results: There are unaddressed questions for the regulator with regard to the unsolved dynamic of heterogeneity and variations of the quality profile, which have potential implications on safety and efficacy. This is neglected and not taken into account seriously enough by the stakeholders. Solution: Further, the only (in my view) progressive way to deal with such foreseeable situations from the biosimilar developers point of view is to incorporate a design space. The author works in the life-science industry for over 7 years now. His educational and scientific background is in immunology, as he graduated at the Max Planck Institute for Immunology in Freiburg. Further he completed a MSc. in pharmaceutical quality a
This volume of Progress in Molecular Biology and Translational Science introduces emerging strategies of studying RNA structure and function using nanotechnological tools. The volume aims to provide the readers with a novel view and give them opportunities to think about how to incorporate the new technologies into their own research. This book informs and updates on strategies to take advantages of nanotechnological tools to answer to fundamental questions in RNA science Collection of reviews written by the leading scientists from the field The book covers a range of topics, from single molecule analyses using nanomaterials to gene regulation using RNA nanostructures